Neurosyphilis - the white matter disintegration? - two case reports.

Dementia and white-matter demyelination in young patient with neurosyphilis.

MR findings in neurosyphilis--a literature review with a focus on a practical approach to neuroimaging.

BACKGROUND Syphilis is a sexually transmitted disease caused by Treponema pallium. The invasion of the central nervous system is observed in 5-10% of untreated patients and may occur at any stage of the disease. The diagnosis of the early stage of syphilitic infection is complex as many patients present either nonspecific symptoms or are asymptomatic. The identification of the most common radio...

Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings.

PURPOSE To evaluate and describe the neuroimaging findings of patients with neurosyphilis. METHODS The neuroimaging studies of 35 patients with documented neurosyphilis were reviewed. Diagnosis was established in 34 patients with cerebrospinal fluid for a Venereal Disease Research Laboratory test, complemented by autopsy in 1 and brain biopsy in 1. All patients had reactive fluorescent trepon...

Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion.

BACKGROUND AND PURPOSE Chronic cerebral hypoperfusion can lead to ischemic white matter injury resulting in vascular dementia. To characterize white matter injury in vascular dementia, we investigated disintegration of diverse white matter components using a rat model of chronic cerebral hypoperfusion. METHODS Chronic cerebral hypoperfusion was modeled in Wistar rats by permanent occlusion of...

The pattern of diffusion parameter changes in Alzheimer's disease, identified by means of linked independent component analysis.

Several recent studies have indicated that white matter is affected in Alzheimer's disease (AD). Diffusion tensor imaging is a tool by which the white matter microstructure can be examined in vivo, and might offer a possibility for the identification of the pattern of white matter disintegration in AD. In the current analysis, we made use of a novel model-free analysis approach of linked indepe...